Differential diagnosis of Generalized weakness / tiredness



Mnemonic for Differential diagnosis of Generalized weakness / tiredness

ABCDEFGHI (examples in brackets)
  • Autoimmune disease (coeliac disease, multiple sclerosis)
  • Blood disorders (anemia)
  • Cancer / Chronic fatigue syndrome
  • Depression and other depressive mental disorders
  • Endocrine (diabetes mellitus, hypothyroid) / Eating disorders
  • Fibromyalgia (muscle pain)
  • Generalized infection (Infectious mononucleosis by EBV)
  • Heart disease
  • Immune deficiency (HIV/AIDS)
Other conditions:
  • Leukemia / lymphoma
  • Neurological disorders (Parkinson’s disease)
  • Physical trauma
  • Pregnancy
  • Sleep deprivation
  • Hepatic failure
  • Uremia



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