Mnemonic for Fever / Pyrexia of unknown origin causes
Infections Can Make Undergraduates Die
Pyrexia of unknown origin (PUO) is a fever > 3 weeks with no cause found despite 7 days in hospital with investigations.
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- Infection (20-40%)
- Tuberculosis
- Infective endocarditis
- Epstein-Barr virus (EBV)
- Cytomegalovirus (CMV)
- Connective tissue disorders (20%)
- Rheumatoid arthritis
- Systemic Lupus Erythematosus
- Adult-onset Still’s disease
- Temporal arteritis
- Malignancy (10-20%)
- Lymphoma
- Leukaemia
- Hepatocellular carcinoma
- Undiagnosed (20%)
- Drugs (e.g. phenytoin) (Rare)
Pyrexia of unknown origin (PUO) is a fever > 3 weeks with no cause found despite 7 days in hospital with investigations.
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