Mnemonic for Psoriasis pathogenesis
HARP
Absent granular layer and infiltration of neutrophils and activated lymphocytes (from dermis to epidermis)
Nail changes (occur in 50% of patients)
STOP
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- Hyperkeratosis – thickening of cornified layer
- Acanthosis – epidermal thickening (3-5 times normal)
- Rete ridge elongation (arrowheads)
- Parakeratosis – retained nuclei in stratum corneum
Absent granular layer and infiltration of neutrophils and activated lymphocytes (from dermis to epidermis)
Nail changes (occur in 50% of patients)
STOP
- Subungual hyperkeratosis (proliferation under nail bed)
- Thickening
- Onycholysis (separation from the nail bed)
- Pitting, ridging
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