Mnemonic for the causes of Splenomegaly
CHIMP:
Cysts
Haematological ( eg CML, myelofibrosis)
Infective (eg viral (IM), bacterial)
Metabolic/ Misc (eg amyloid, Gauchers)
Portal hypertension
Another mnemonic
HICCUPS
Haematological
Infective : Kala azar, malaria, enteric fever
Congestive: CCF, constrictive pericarditis, IVC thrombosis, Hepatic vein thrombosis, portal vein thrombosis and splenic vein thrombosis
Collagen diseases: SLE, Felty's syndrome
Unknown etiology: tropical splenomegaly
Primary malignacies (secondaries are rare)
Storage diseases: Gaucher's disease, Niemman Pick
Another mnemonic
CHINA
Congestion/ Cellular infiltration
Haematological (eg haemolytic anaemia, Sickle cell)
Infection/ Infarction (eg malaria, GF, CMV)
Neoplasia (eg CML, lymphoma, other myeloproliferative)
Autoimmune
Causes of Massive splenomegaly (three M’s):
- chronic Myeloid leukaemia
- Myelofibrosis
- Malaria
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