Vitamin D metabolism

UV rays from sun act on skin, convert Cholecalciferol (CC) --> 25 Hydroxy CC in liver --> 1,25 Di Hydroxy CC in kidney.
So there are two hydroxylation reactions, first in Liver, second in Kidney. Remember this: You have 1 liver, 2 kidneys; So hydroxylation 1st reaction in your 1 liver and 2nd hydroxylation in 2 kidneys.


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